Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21864818 | 1.00 | DGAT1 (0.41) | DGAT1HIF1APDGFRBKDRPIK3CA | |
| SCHEMBL25455442 | 0.89 | DGAT1 (0.43) | DGAT1HIF1APDGFRBKDRPIK3CA | |
| SCHEMBL25453515 | 0.86 | PIK3CA (0.34) | DGAT1HIF1APIK3CAADORA1POLB | |
| SCHEMBL29545777 | 0.80 | EGFR (0.39) | DGAT1CA1CA2CA9IDO1 | |
| SCHEMBL1368949 | 0.80 | EGFR (0.39) | DGAT1CA1CA2CA9IDO1 | |
| SCHEMBL25454628 | 0.80 | DGAT1 (0.36) | DGAT1HIF1AGSK3AGSK3BPRMT5 | |
| SCHEMBL23839128 | 0.77 | SYK (0.51) | PRMT5WDR77 | |
| SCHEMBL21864816 | 0.76 | SYK (0.44) | PIK3CAADORA1POLBF2 | |
| SCHEMBL10828998 | 0.76 | KMT2A (0.46) | PIK3CAADORA1POLB | |
| SCHEMBL30161518 | 0.76 | DGAT1 (0.43) | DGAT1HIF1APDGFRBKDRGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4107146-A1 | GCN2 MODULATOR COMPOUNDS | Alesta Therapeutics BV (NL) | 2022-12-28 | — | — | EP | disclosed |