Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10831709 | 0.90 | MAPT (0.43) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL10925793 | 0.87 | KCNH2 (0.44) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL10832655 | 0.84 | KMT2A (0.40) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL10832448 | 0.83 | KMT2A (0.53) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL10832100 | 0.83 | ALDH1A1 (0.50) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL7276308 | 0.83 | HTR2A (0.57) | CHRM3HTR2AHTR2CALDH1A1 | |
| Iodomethane SCHEMBL7277612 | 0.82 | HTR2A (0.56) | CHRM3HTR2AHTR2CALDH1A1 | |
| SCHEMBL10831617 | 0.81 | HTR2A (0.63) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL11054892 | 0.81 | KMT2A (0.51) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL10832635 | 0.80 | HTR2A (0.55) | KMT2AMAPTMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4582848-A | 2-substituted-3-indolamines and use thereof as anti-diabetics | SANDOZ, INC. (US) | 1986-04-15 | — | — | US | disclosed |
| US-4544663-A | ASPERMATOGENESIS INDUCERS | SANDOZ, INC. (US) | 1985-10-01 | — | — | US | disclosed |
| US-4536499-A | Isoxazolyl indolamines having anti-diabetic activity | SANDOZ, INC. (US) | 1985-08-20 | — | — | US | disclosed |