Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10832252 | 0.95 | HTR6 (0.49) | HTR6SLC6A4HTR1AHTR1DHTR7 | |
| SCHEMBL10922515 | 0.89 | CYP1A2 (0.44) | CSF1RPTGS1PTGS2MAPTKMT2A | |
| SCHEMBL10832635 | 0.89 | HTR2A (0.55) | HTR6SLC6A4HTR1AHTR1DHTR7 | |
| SCHEMBL10832217 | 0.85 | HTR2A (0.51) | HTR6SLC6A4HTR1AHTR1DHTR7 | |
| SCHEMBL10924722 | 0.85 | PPARG (0.46) | CSF1RPTGS1PTGS2MAPTKMT2A | |
| SCHEMBL10831617 | 0.84 | HTR2A (0.63) | HTR6SLC6A4HTR1AHTR1DHTR7 | |
| SCHEMBL10831709 | 0.82 | MAPT (0.43) | CSF1RMAPTKMT2ANPSR1MGAM | |
| SCHEMBL10832592 | 0.82 | HTR6 (0.69) | HTR6SLC6A4HTR1AHTR1DHTR7 | |
| SCHEMBL10923170 | 0.82 | CSF1R (0.44) | CSF1RPTGS1PTGS2MAPTKMT2A | |
| SCHEMBL10832528 | 0.81 | KMT2A (0.41) | CSF1RPTGS1PTGS2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4582848-A | 2-substituted-3-indolamines and use thereof as anti-diabetics | SANDOZ, INC. (US) | 1986-04-15 | — | — | US | disclosed |
| US-4544663-A | ASPERMATOGENESIS INDUCERS | SANDOZ, INC. (US) | 1985-10-01 | — | — | US | disclosed |
| US-4536499-A | Isoxazolyl indolamines having anti-diabetic activity | SANDOZ, INC. (US) | 1985-08-20 | — | — | US | disclosed |