SCHEMBL1083240

SCHEMBL1083240

c1ccc(Cc2ncc[nH]2)nc1

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 9/20 0.61
HRH3 Q9Y5N1 2/20 0.50
HRH4 Q9H3N8 1/20 0.50
ADRA2A P08913 1/20 0.50
ADRA2B P18089 1/20 0.50
ADRA2C P18825 1/20 0.50
HTR1A P08908 1/20 0.49
MAPT P10636 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
LIN28A Q9H9Z2 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.44
F2 P00734 1/20 0.43
F10 P00742 1/20 0.43
F7 P08709 1/20 0.43
CYP2D6 P10635 1/20 0.42
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10511418 0.83 HRH3 (0.51) TAAR1HRH3HRH4MAPTSMN1; SMN2
SCHEMBL1585966 0.82 TAAR1 (0.58) TAAR1ADRA2AADRA2BADRA2CHTR1A
SCHEMBL17489127 0.78 HRH3 (0.50) TAAR1HRH3HRH4MAPTSMN1; SMN2
SCHEMBL28103549 0.78 ADRA2A (0.69) TAAR1ADRA2AADRA2BADRA2CHTR1A
SCHEMBL14029841 0.76 TAAR1 (0.56) TAAR1MAPTSMN1; SMN2LIN28ATDP1
SCHEMBL1679282 0.76 TAAR1 (0.64) TAAR1ADRA2AADRA2BADRA2CHTR1A
SCHEMBL29830938 0.76 L3MBTL1 (0.59) TAAR1HRH3HRH4MAPTSMN1; SMN2
SCHEMBL41191 0.76 L3MBTL1 (0.59) TAAR1HRH3HRH4MAPTSMN1; SMN2
SCHEMBL9243 0.76 TAAR1 (1.00) TAAR1ADRA2AADRA2BADRA2CHTR1A
SCHEMBL29748356 0.76 TAAR1 (0.59) TAAR1ADRA2AADRA2BADRA2CHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5194491-A None JP disclosed
US-8961822-B2 Metallocarbene complex peroxide activators ARKEMA INC. (US) 2015-02-24 US disclosed
US-20130190219-A1 METALLOCARBENE COMPLEX PEROXIDE ACTIVATORS ARKEMA INC. (US) 2013-07-25 US disclosed
EP-2274314-B1 METALLOCARBENE COMPLEX PEROXIDE ACTIVATORS ARKEMA INC (US) 2013-07-17 EP disclosed
US-8414793-B2 Metallocarbene complex peroxide activators ARKEMA INC. (US) 2013-04-09 US disclosed
EP-1919477-B1 Use of [2-(2-methylimidazol-1-yl)methyl]pyridine for treating sleep disorders VANDA PHARMACEUTICALS INC (US) 2012-07-11 EP disclosed
US-20110147654-A1 METALLOCARBENE COMPLEX PEROXIDE ACTIVATORS ARKEMA INC. (US) 2011-06-23 US disclosed
EP-2274314-A1 METALLOCARBENE COMPLEX PEROXIDE ACTIVATORS Arkema Inc. (US) 2011-01-19 EP disclosed
WO-2009140259-A1 METALLOCARBENE COMPLEX PEROXIDE ACTIVATORS ARKEMA INC. (US) 2009-11-19 WO disclosed
WO-2009097416-A1 IMIDAZOLYLALKYL- PYRIDINES AS DBH INHIBITORS VANDA PHARMACEUTICALS, INC. (US) 2009-08-06 WO disclosed
EP-0534904-B1 Imidazolylmethyl-pyridines SANDOZ LTD (CH) 1996-10-23 EP disclosed
CN-1088925-A Imidazolylmethyl-pyridines SANDOZ LTD (CH) 1994-07-06 CN disclosed
CN-1088925-A Imidazolylmethyl-pyridines SANDOZ LTD (CH) 1994-07-06 CN disclosed
JP-H05194491-A IMIDAZOLYLMETHYL-PYRIDINE SANDOZ AG 1993-08-03 JP disclosed
EP-0534904-A1 Imidazolylmethyl-pyridines SANDOZ LTD. (CH) 1993-03-31 EP disclosed
EP-0534904-A1 Imidazolylmethyl-pyridines SANDOZ LTD. (CH) 1993-03-31 EP disclosed
US-4666683-A WATER INSOLUBLE ION EXCHANGE RESIN ECO-TEC LIMITED (CA) 1987-05-19 US disclosed
US-4339583-A (Imidazolylmethyl)pyridine compounds as thromboxane synthetase inhibitors PFIZER INC. (US) 1982-07-13 US disclosed
US-4339583-A (Imidazolylmethyl)pyridine compounds as thromboxane synthetase inhibitors PFIZER INC. (US) 1982-07-13 US disclosed
EP-0029742-A1 Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof Pfizer Limited (GB) 1981-06-03 EP disclosed