Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CRHBP | P24387 | 2/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19031988 | 0.83 | ENPP2 (0.38) | ENPP2KDM4ECA1CA2 | |
| SCHEMBL1895322 | 0.80 | PRKCI (0.40) | ENPP2CA1CA2 | |
| SCHEMBL121851 | 0.77 | TSHR (0.46) | LMNASMN1; SMN2HTTMAPTBLM | |
| SCHEMBL29953828 | 0.75 | ENPP2 (0.35) | ENPP2KDM4ECA1CA2 | |
| SCHEMBL29951836 | 0.74 | ENPP2 (0.39) | ENPP2KDM4ECA1CA2 | |
| SCHEMBL1083349 | 0.73 | ENPP2 (0.36) | ENPP2KDM4ECA1CA2 | |
| SCHEMBL8251512 | 0.73 | MAPT (0.41) | LMNASMN1; SMN2CRHBPCRHR2HTT | |
| SCHEMBL8282741 | 0.73 | MAPT (0.61) | LMNASMN1; SMN2CRHBPCRHR2HTT | |
| SCHEMBL8475 | 0.71 | NPC1 (0.45) | LMNASMN1; SMN2HTTMAPTENPP2 | |
| SCHEMBL29789730 | 0.71 | NPC1 (0.45) | LMNASMN1; SMN2HTTMAPTENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271646-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009123986-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | WO | disclosed |