Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 4/20 | 0.38 |
| ▸ | MMP1 | P03956 | 4/20 | 0.37 |
| ▸ | MMP3 | P08254 | 4/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10833244 | 0.84 | F2 (0.42) | F2F10PRSS1GAAMMP1 | |
| SCHEMBL8234659 | 0.82 | F2 (0.50) | F2F10PRSS1GAAPLA2G10 | |
| SCHEMBL8234664 | 0.82 | F2 (0.50) | F2F10PRSS1GAAPLA2G10 | |
| SCHEMBL5903395 | 0.81 | SRC (0.42) | F2F10PRSS1GAASRC | |
| SCHEMBL7428585 | 0.80 | CASP1 (0.43) | F2F10PRSS1GAASRC | |
| SCHEMBL4760675 | 0.79 | F2 (0.48) | F2F10PRSS1GAAMMP1 | |
| SCHEMBL12525646 | 0.79 | MMP1 (0.55) | F2F10PRSS1GAAMMP1 | |
| SCHEMBL12494289 | 0.79 | MMP1 (0.55) | F2F10PRSS1GAAMMP1 | |
| SCHEMBL7292123 | 0.78 | F2 (0.51) | F2F10PRSS1GAAFPR2 | |
| SCHEMBL8081478 | 0.78 | F2 (0.51) | F2F10PRSS1GAAFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4594341-A | Hypotensive agent | MERCK & CO., INC. (US) | 1986-06-10 | — | — | US | disclosed |
| EP-0068173-B1 | PERHYDRO-1,4-THIAZEPIN-5-ONE AND PERHYDRO-1,4-THIAZOCIN-5-ONE DERIVATIVES, PROCESS FOR PREPARING AND PHARMCEUTICAL COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1984-09-26 | — | — | EP | disclosed |
| EP-0068173-A1 | Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives, process for preparing and pharmceutical composition containing the same | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | disclosed |