Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.61 |
| ▸ | DRD3 | P35462 | 9/20 | 0.61 |
| ▸ | DRD2 | P14416 | 7/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | PRCP | P42785 | 1/20 | 0.61 |
| ▸ | EBP | Q15125 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 7/20 | 0.55 |
| ▸ | DRD1 | P21728 | 7/20 | 0.55 |
| ▸ | DRD5 | P21918 | 7/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10834584 | 0.81 | DRD2 (0.60) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL7352815 | 0.79 | DRD3 (0.85) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL7323429 | 0.79 | DRD3 (0.85) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL7308634 | 0.78 | DRD3 (0.85) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| Hydrochloric Acid SCHEMBL7316658 | 0.77 | DRD3 (0.83) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| SCHEMBL9582690 | 0.76 | DRD3 (0.76) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| Preclamol SCHEMBL29414104 | 0.76 | DRD3 (1.00) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| Preclamol SCHEMBL872804 | 0.76 | DRD3 (1.00) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| Preclamol SCHEMBL30730528 | 0.76 | DRD3 (1.00) | DRD4DRD3DRD2SIGMAR1NFKB1 | |
| Hydrochloric Acid SCHEMBL7314840 | 0.76 | DRD3 (0.76) | DRD4DRD3DRD2SIGMAR1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4623728-A | NERVOUS SYSTEM DISORDERS | PFIZER INC. (US) | 1986-11-18 | — | — | US | disclosed |
| US-4593037-A | Compound substituted with phenyl rings | PFIZER INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0175452-A1 | 1,3-Disubstituted piperidine compounds as neuroleptic agents | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |