Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | DRD3 | P35462 | 5/20 | 0.58 |
| ▸ | DRD4 | P21917 | 4/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | PRCP | P42785 | 1/20 | 0.58 |
| ▸ | EBP | Q15125 | 1/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | DRD1 | P21728 | 3/20 | 0.53 |
| ▸ | DRD5 | P21918 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10834383 | 0.86 | DRD2 (0.61) | DRD2DRD3MEN1KMT2AHTR1A | |
| SCHEMBL18937874 | 0.83 | DRD4 (0.67) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| SCHEMBL6353997 | 0.81 | ALDH1A1 (0.69) | DRD2DRD3DRD4SIGMAR1MEN1 | |
| SCHEMBL10835280 | 0.81 | DRD4 (0.61) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| SCHEMBL7323429 | 0.77 | DRD3 (0.85) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| SCHEMBL7352815 | 0.77 | DRD3 (0.85) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| SCHEMBL4050900 | 0.77 | DRD3 (0.60) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL7308634 | 0.76 | DRD3 (0.85) | DRD2DRD3DRD4SIGMAR1NFKB1 | |
| SCHEMBL20652674 | 0.75 | DRD2 (1.00) | DRD2DRD3DRD4SIGMAR1MEN1 | |
| Hydrochloric Acid SCHEMBL7316658 | 0.75 | DRD3 (0.83) | DRD2DRD3DRD4SIGMAR1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4623728-A | NERVOUS SYSTEM DISORDERS | PFIZER INC. (US) | 1986-11-18 | — | — | US | disclosed |
| US-4593037-A | Compound substituted with phenyl rings | PFIZER INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0175452-A1 | 1,3-Disubstituted piperidine compounds as neuroleptic agents | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |