Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10838470 | 0.76 | LMNA (0.51) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL10663277 | 0.76 | LMNA (0.48) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL20037217 | 0.76 | MEN1 (0.60) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL10663268 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL10663271 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL20083710 | 0.74 | NPC1 (0.66) | SMN1; SMN2ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL11665650 | 0.72 | LMNA (0.59) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL17151048 | 0.72 | LMNA (1.00) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL20037163 | 0.71 | HTT (0.55) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL6966371 | 0.71 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4608383-A | Cardioactive pyrazole and imidazole aryloxypropanolamines | BOEHRINGER MANNHEIM GMBH (DE) | 1986-08-26 | — | — | US | disclosed |
| US-4507488-A | N-Pyrazolylalkylenediamine intermediates | BOEHRINGER MANNHEIM GMBH (DE) | 1985-03-26 | — | — | US | disclosed |
| US-4438128-A | ADRENERGIC BLOCKERS | BOEHRINGER MANNHEIM GMBH (DE) | 1984-03-20 | — | — | US | disclosed |
| EP-0042592-A1 | N-heteroarylalkylene diamines, process for their preparation and their use | Roche Diagnostics GmbH (DE) | 1981-12-30 | — | — | EP | disclosed |