Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.38 |
| ▸ | TXK | P42681 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18411114 | 0.77 | IDO1 (0.41) | LYNTXKSYKBTKIDO1 | |
| SCHEMBL25791157 | 0.73 | AKT2 (0.43) | ROCK2ROCK1IDO1JAK2JAK1 | |
| SCHEMBL21986879 | 0.72 | NOS1 (0.42) | IDO1MAP4K1NOS1AXL | |
| SCHEMBL7572136 | 0.72 | JAK2 (0.55) | IDO1TDO2JAK2JAK1NR3C1 | |
| SCHEMBL17389142 | 0.71 | CHEK1 (0.45) | ROCK2ROCK1PKN2ALDH1A1HTT | |
| SCHEMBL3534803 | 0.70 | MAPT (0.52) | ROCK2ROCK1IDO1TDO2ALDH1A1 | |
| SCHEMBL8404436 | 0.69 | IDO1 (0.46) | IDO1JAK2JAK1NOS1AXL | |
| SCHEMBL16103842 | 0.69 | MAP2K1 (0.60) | LYNTXKSYKBTKMAP2K1 | |
| SCHEMBL20850537 | 0.67 | CDK2 (0.43) | IDO1MAP4K1NOS1AXL | |
| SCHEMBL6445802 | 0.67 | CA12 (0.42) | SYKIDO1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4608383-A | Cardioactive pyrazole and imidazole aryloxypropanolamines | BOEHRINGER MANNHEIM GMBH (DE) | 1986-08-26 | — | — | US | disclosed |
| EP-0042593-B1 | ARYLOXY-PROPANOL AMINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1985-04-03 | — | — | EP | disclosed |
| US-4507488-A | N-Pyrazolylalkylenediamine intermediates | BOEHRINGER MANNHEIM GMBH (DE) | 1985-03-26 | — | — | US | disclosed |
| EP-0042592-B1 | N-HETEROARYLALKYLENE DIAMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE | Roche Diagnostics GmbH (DE) | 1985-01-30 | — | — | EP | disclosed |
| US-4438128-A | ADRENERGIC BLOCKERS | BOEHRINGER MANNHEIM GMBH (DE) | 1984-03-20 | — | — | US | disclosed |
| EP-0042592-A1 | N-heteroarylalkylene diamines, process for their preparation and their use | Roche Diagnostics GmbH (DE) | 1981-12-30 | — | — | EP | disclosed |
| EP-0042593-A1 | Aryloxy-propanol amines, process for their preparation and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1981-12-30 | — | — | EP | disclosed |