Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.85 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.85 |
| ▸ | MEN1 | O00255 | 5/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.85 |
| ▸ | LMNA | P02545 | 4/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.85 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.85 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.69 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | PDE5A | O76074 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1056599 | 0.92 | ABCG2 (1.00) | MAPTABCG2MEN1KMT2AKDM4E | |
| SCHEMBL1083772 | 0.87 | MAPT (0.87) | MAPTABCG2MEN1KMT2AKDM4E | |
| SCHEMBL16404471 | 0.81 | MAPT (0.73) | MAPTABCG2MEN1KMT2AKDM4E | |
| SCHEMBL22201652 | 0.81 | LMNA (1.00) | MAPTABCG2MEN1KMT2AKDM4E | |
| SCHEMBL1083764 | 0.80 | ABCG2 (1.00) | MAPTABCG2MEN1KMT2AKDM4E | |
| SCHEMBL22201361 | 0.80 | ABCG2 (1.00) | MAPTABCG2MEN1KMT2AKDM4E | |
| SCHEMBL5801597 | 0.79 | ABCG2 (0.82) | MAPTABCG2MEN1KMT2AKDM4E | |
| SCHEMBL7434986 | 0.78 | ALDH1A1 (1.00) | MAPTABCG2MEN1KMT2AKDM4E | |
| SCHEMBL14262837 | 0.78 | KDM4E (0.94) | MAPTABCG2MEN1KMT2AKDM4E | |
| SCHEMBL5101433 | 0.78 | ABCG2 (0.74) | MAPTABCG2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |