Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.55 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10841118 | 1.00 | OPRM1 (0.55) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| SCHEMBL10842196 | 0.93 | OPRM1 (0.63) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Citric Acid SCHEMBL10842456 | 0.91 | OPRM1 (0.52) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Citric Acid SCHEMBL10842442 | 0.91 | OPRM1 (0.52) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Oxalic Acid SCHEMBL10842320 | 0.91 | OPRM1 (0.61) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Oxalic Acid SCHEMBL10842300 | 0.91 | OPRM1 (0.61) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Citric Acid SCHEMBL10842847 | 0.87 | OPRM1 (0.45) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Citric Acid SCHEMBL10842856 | 0.87 | OPRM1 (0.45) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| SCHEMBL5617037 | 0.82 | OPRM1 (0.59) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| SCHEMBL10843810 | 0.82 | OPRM1 (0.61) | OPRM1SLC22A1ABCB1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4584303-A | ANALGESICS | THE BOC GROUP, INC. (US) | 1986-04-22 | — | — | US | disclosed |
| EP-0160422-A1 | N-Aryl-N-(4-Piperidinyl)amides and pharmaceutical compositions and methods employing such compounds | Anaquest, Inc. (US) | 1985-11-06 | — | — | EP | disclosed |