Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | USP1 | O94782 | 3/20 | 0.67 |
| ▸ | WDR48 | Q8TAF3 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.67 |
| ▸ | APP | P05067 | 2/20 | 0.65 |
| ▸ | PDE5A | O76074 | 3/20 | 0.64 |
| ▸ | GBA1 | P04062 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12176090 | 0.95 | LMNA (0.72) | MEN1KMT2ALMNAMAPTUSP1 | |
| SCHEMBL12176088 | 0.93 | LMNA (0.76) | MEN1KMT2ALMNAMAPTUSP1 | |
| SCHEMBL27899407 | 0.91 | LMNA (0.67) | MEN1KMT2ALMNAMAPTUSP1 | |
| SCHEMBL4866252 | 0.90 | PDE5A (0.78) | MEN1KMT2ALMNAMAPTUSP1 | |
| SCHEMBL12176338 | 0.90 | PDE5A (0.78) | MEN1KMT2ALMNAMAPTUSP1 | |
| SCHEMBL2583554 | 0.88 | MEN1 (1.00) | MEN1KMT2ALMNAMAPTUSP1 | |
| SCHEMBL1084183 | 0.88 | MEN1 (0.89) | MEN1KMT2ALMNAMAPTUSP1 | |
| SCHEMBL27899411 | 0.87 | MEN1 (0.83) | MEN1KMT2ALMNAMAPTUSP1 | |
| SCHEMBL12176337 | 0.84 | PDE5A (0.85) | MEN1KMT2ALMNAMAPTUSP1 | |
| SCHEMBL3121699 | 0.84 | APP (0.73) | MEN1KMT2ALMNAMAPTUSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103068393-A | Methods and compositions for inhibition of the transitional endoplasmic reticulum atpase | CLEAVE BIOSCIENCES INC CLEAVE | 2013-04-24 | — | — | CN | disclosed |
| EP-2566480-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | California Institute of Technology (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |