Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.81 |
| ▸ | PDE5A | O76074 | 7/20 | 0.81 |
| ▸ | GBA1 | P04062 | 2/20 | 0.81 |
| ▸ | ATM | Q13315 | 1/20 | 0.81 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.73 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | APP | P05067 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.65 |
| ▸ | USP2 | O75604 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4864013 | 0.94 | PDE5A (0.81) | MEN1KMT2APDE5AGBA1ATM | |
| SCHEMBL1083763 | 0.90 | PDE5A (1.00) | MEN1KMT2APDE5AGBA1ATM | |
| SCHEMBL1084183 | 0.87 | MEN1 (0.89) | MEN1KMT2APDE5AGBA1ATM | |
| SCHEMBL3980498 | 0.86 | PDE5A (0.65) | MEN1KMT2APDE5AGBA1ATM | |
| SCHEMBL2583256 | 0.86 | PDE5A (0.90) | MEN1KMT2APDE5AGBA1ATM | |
| SCHEMBL12176300 | 0.86 | MEN1 (0.81) | MEN1KMT2APDE5AGBA1ATM | |
| SCHEMBL3977603 | 0.86 | PDE5A (0.70) | MEN1KMT2APDE5AGBA1ATM | |
| SCHEMBL3981851 | 0.86 | PDE5A (0.70) | MEN1KMT2APDE5AGBA1ATM | |
| SCHEMBL4863906 | 0.85 | PDE5A (0.75) | MEN1KMT2APDE5AGBA1ATM | |
| SCHEMBL7277479 | 0.84 | PDE5A (1.00) | MEN1KMT2APDE5AGBA1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103068393-A | Methods and compositions for inhibition of the transitional endoplasmic reticulum atpase | CLEAVE BIOSCIENCES INC CLEAVE | 2013-04-24 | — | — | CN | disclosed |
| EP-2566480-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | California Institute of Technology (US) | 2013-03-13 | — | — | EP | disclosed |
| US-8263642-B2 | Antimicrobial compounds and methods of use thereof | VANDERBILT UNIVERSITY (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263642-B2 | Antimicrobial compounds and methods of use thereof | VANDERBILT UNIVERSITY (US) | 2012-09-11 | — | — | US | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | VANDERBILT UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | VANDERBILT UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | HMOX1, HMOX2, NOD2 | MEN1 4247/4885KMT2A 4544/4885PDE5A 894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.