Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10846576 | 0.89 | HTR2C (0.61) | ALOX15CREBBPTSHRHTR2CMAPT | |
| SCHEMBL10847434 | 0.82 | ALOX15 (0.80) | ALOX15CREBBPPOLBTSHR | |
| SCHEMBL14765127 | 0.81 | PDE2A (0.53) | POLBNPSR1HTR2C | |
| SCHEMBL7342631 | 0.80 | TYMS (0.56) | POLBNPSR1HTR2CMAPT | |
| SCHEMBL10847813 | 0.79 | ALOX15 (0.60) | ALOX15CREBBPPOLBNPSR1TSHR | |
| SCHEMBL10847230 | 0.79 | ALOX15 (0.58) | ALOX15CREBBPPOLBNPSR1TSHR | |
| SCHEMBL10848015 | 0.78 | ALOX15 (0.56) | ALOX15CREBBPNPSR1TSHRMAPT | |
| SCHEMBL10845557 | 0.77 | HTR2C (0.63) | HTR2CMAPT | |
| SCHEMBL10844925 | 0.75 | HTR2C (0.54) | ALOX15CREBBPHTR2CMAPT | |
| SCHEMBL15033502 | 0.75 | ALOX15 (1.00) | ALOX15CREBBPPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4623725-A | [1,2,4]Triazolo[4,3-a]quinoxaline-4-amine derivatives | PFIZER INC. (US) | 1986-11-18 | — | — | US | disclosed |
| EP-0107455-B1 | TRIAZOLOQUINOXALINES AS ANTIDEPRESSANTS AND ANTIFATIGUE AGENTS | PFIZER INC. (US) | 1986-07-09 | — | — | EP | disclosed |
| US-4547501-A | Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents | PFIZER INC. (US) | 1985-10-15 | — | — | US | disclosed |
| US-4495187-A | Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents | PFIZER INC. (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0107455-A1 | Triazoloquinoxalines as antidepressants and antifatigue agents | PFIZER INC. (US) | 1984-05-02 | — | — | EP | disclosed |