Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14354843 | 0.90 | POLB (0.54) | PDE2APDE10AHTR2CPOLBNPSR1 | |
| SCHEMBL7342631 | 0.84 | TYMS (0.56) | HTR2CPOLBNPSR1 | |
| SCHEMBL10844192 | 0.81 | ALOX15 (0.60) | HTR2CPOLBNPSR1 | |
| SCHEMBL971822 | 0.79 | PDE10A (0.63) | PDE2APDE10A | |
| SCHEMBL14765137 | 0.77 | PDE2A (0.56) | PDE2APDE10AHTR2C | |
| SCHEMBL7347836 | 0.76 | NPSR1 (0.54) | HTR2CPOLBNPSR1 | |
| SCHEMBL14764825 | 0.76 | PDE10A (0.58) | PDE2APDE10A | |
| SCHEMBL14054782 | 0.75 | PDE2A (0.67) | PDE2APDE10APOLB | |
| SCHEMBL7345568 | 0.75 | ALDH1A1 (0.69) | HTR2C | |
| SCHEMBL28574640 | 0.75 | KDM4E (0.78) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | claimed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |