Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.56 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | PDE9A | O76083 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10850002 | 0.86 | SLC6A2 (0.48) | HRH3PDE9ACYP2D6KCNH2 | |
| SCHEMBL10807365 | 0.85 | CYP2D6 (0.53) | HRH3NAAAPDE9ACYP2D6OPRD1 | |
| SCHEMBL10850553 | 0.83 | CYP2D6 (0.47) | NAAAPDE9ACYP2D6OPRD1 | |
| SCHEMBL10850169 | 0.83 | CYP2D6 (0.47) | HRH3NAAAPDE9ACYP2D6MEN1 | |
| SCHEMBL20068919 | 0.83 | HRH3 (0.73) | HRH3NAAAPDE9AGRIN1GRIN2B | |
| SCHEMBL10850371 | 0.78 | PDE9A (0.46) | HRH3PDE9ACYP2D6MEN1KMT2A | |
| SCHEMBL10850217 | 0.77 | SRD5A1 (0.45) | CYP2D6OPRD1KCNH2 | |
| SCHEMBL10851860 | 0.76 | OPRK1 (0.52) | CYP2D6OPRD1KMT2AKCNH2 | |
| SCHEMBL10854349 | 0.76 | CYP2D6 (0.46) | PDE9ACYP2D6OPRD1KCNH2 | |
| SCHEMBL4236739 | 0.75 | HRH3 (0.84) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102740-B1 | N-FORMYL AND N-HYDROXYMETHYL-3-PHENOXY-1-AZETIDINECARBOXAMIDES AND THEIR PREPARATION AND USE | A.H. ROBINS COMPANY, INCORPORATED (US) | 1986-11-05 | — | — | EP | disclosed |
| EP-0102194-B1 | 3-PHENOXY-1-AZETIDINECARBOXAMIDES AND THEIR USE AND PREPARATION | A.H. ROBINS COMPANY, INCORPORATED (US) | 1986-10-22 | — | — | EP | disclosed |
| US-4571393-A | ANTICONVULSANT TREATMENT FOR MAMMALS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-02-18 | — | — | US | disclosed |
| US-4505907-A | ANTICONVULSANTS | A. H. ROBINS COMPANY, INC. (US) | 1985-03-19 | — | — | US | disclosed |
| EP-0102740-A1 | N-formyl and n-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides and their preparation and use | A.H. ROBINS COMPANY, INCORPORATED (US) | 1984-03-14 | — | — | EP | disclosed |
| EP-0102194-A1 | 3-Phenoxy-1-azetidinecarboxamides and their use and preparation | A.H. ROBINS COMPANY, INCORPORATED (US) | 1984-03-07 | — | — | EP | disclosed |