Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 7/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10845441 | 0.86 | HRH3 (0.56) | PDE9AKCNH2HRH3CYP2D6 | |
| SCHEMBL10807365 | 0.82 | CYP2D6 (0.53) | SLC6A2SLC6A4SLC6A3PDE9AOPRK1 | |
| SCHEMBL10851128 | 0.81 | PDE9A (0.47) | SLC6A2SLC6A4SLC6A3PDE9AOPRK1 | |
| SCHEMBL10848810 | 0.81 | SLC6A4 (0.45) | SLC6A2SLC6A4SLC6A3PDE9AMGLL | |
| SCHEMBL16382665 | 0.78 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3PDE9AMGLL | |
| SCHEMBL9682477 | 0.78 | PDE9A (0.49) | SLC6A2SLC6A4SLC6A3PDE9AMGLL | |
| SCHEMBL4236282 | 0.77 | DRD2 (0.61) | SLC6A2SLC6A4SLC6A3PDE9AMGLL | |
| Oxalic Acid SCHEMBL10846056 | 0.76 | OPRK1 (0.67) | OPRK1KCNH2OPRM1 | |
| SCHEMBL10854349 | 0.76 | CYP2D6 (0.46) | PDE9AOPRK1KCNH2OPRM1CYP2D6 | |
| Oxalic Acid SCHEMBL10846451 | 0.76 | OPRK1 (0.47) | SLC6A2SLC6A4SLC6A3PDE9AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102740-B1 | N-FORMYL AND N-HYDROXYMETHYL-3-PHENOXY-1-AZETIDINECARBOXAMIDES AND THEIR PREPARATION AND USE | A.H. ROBINS COMPANY, INCORPORATED (US) | 1986-11-05 | — | — | EP | disclosed |
| EP-0102194-B1 | 3-PHENOXY-1-AZETIDINECARBOXAMIDES AND THEIR USE AND PREPARATION | A.H. ROBINS COMPANY, INCORPORATED (US) | 1986-10-22 | — | — | EP | disclosed |
| US-4571393-A | ANTICONVULSANT TREATMENT FOR MAMMALS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-02-18 | — | — | US | disclosed |
| US-4505907-A | ANTICONVULSANTS | A. H. ROBINS COMPANY, INC. (US) | 1985-03-19 | — | — | US | disclosed |
| EP-0102740-A1 | N-formyl and n-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides and their preparation and use | A.H. ROBINS COMPANY, INCORPORATED (US) | 1984-03-14 | — | — | EP | disclosed |
| EP-0102194-A1 | 3-Phenoxy-1-azetidinecarboxamides and their use and preparation | A.H. ROBINS COMPANY, INCORPORATED (US) | 1984-03-07 | — | — | EP | disclosed |
| US-4379151-A | 3-Phenoxyazetidines for anorexigenic activity | A. H. ROBINS COMPANY, INC. (US) | 1983-04-05 | — | — | US | disclosed |