Bromide

Bromide

SCHEMBL10849130

CCCCCCCCCCCC[n+]1ccc(C=Cc2ccc(N(C)C)cc2)cc1.[Br-]

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHKA known ✓ P35790 2/20 0.62
CHRM2 known ✓ P08172 2/20 0.55
CHRM4 known ✓ P08173 2/20 0.55
CHRM5 known ✓ P08912 2/20 0.55
CHRM1 known ✓ P11229 2/20 0.55
CHRM3 known ✓ P20309 2/20 0.55
KDM4A O75164 6/20 0.97
KDM2A Q9Y2K7 6/20 0.97
INSR P06213 3/20 0.57
CHAT P28329 1/20 0.54
MEN1 O00255 4/20 0.54
MAPT P10636 4/20 0.54
KMT2A Q03164 4/20 0.54
HTT P42858 4/20 0.54
SMN1; SMN2 Q16637 3/20 0.54
NPSR1 Q6W5P4 2/20 0.54
APAF1 O14727 1/20 0.54
HSP90AA1 P07900 1/20 0.54
MAPK1 P28482 1/20 0.54
BLM P54132 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL313907 1.00 KDM4A (0.97) KDM4AKDM2ACHKAINSRCHRM2
Bromide SCHEMBL10849127 1.00 KDM4A (0.97) KDM4AKDM2ACHKAINSRCHRM2
Bromide SCHEMBL10845282 1.00 KDM4A (0.97) KDM4AKDM2ACHKAINSRCHRM2
Bromide SCHEMBL10845277 1.00 KDM4A (0.97) KDM4AKDM2ACHKAINSRCHRM2
Bromide SCHEMBL313908 1.00 KDM4A (0.97) KDM4AKDM2ACHKAINSRCHRM2
SCHEMBL10846148 0.98 KDM4A (1.00) KDM4AKDM2ACHKAINSRCHRM2
SCHEMBL13417473 0.98 KDM4A (1.00) KDM4AKDM2ACHKAINSRCHRM2
SCHEMBL21300082 0.98 KDM4A (1.00) KDM4AKDM2ACHKAINSRCHRM2
SCHEMBL10845909 0.98 KDM4A (1.00) KDM4AKDM2ACHKAINSRCHRM2
SCHEMBL10846534 0.98 KDM4A (1.00) KDM4AKDM2ACHKAINSRCHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4608379-A TOPICAL ADMINISTERING JOHN WYETH & BROTHER LIMITED (GB) 1986-08-26 US disclosed
EP-0139440-A2 Pyridinium compounds JOHN WYETH & BROTHER LIMITED (GB) 1985-05-02 EP disclosed