Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.82 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10850700 | 0.93 | SMN1; SMN2 (0.76) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A | |
| SCHEMBL10178027 | 0.90 | SMN1; SMN2 (1.00) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A | |
| SCHEMBL12260494 | 0.88 | SMN1; SMN2 (0.76) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A | |
| SCHEMBL29661994 | 0.87 | SMN1; SMN2 (0.74) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A | |
| SCHEMBL22521953 | 0.87 | SMN1; SMN2 (0.74) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A | |
| Acefylline SCHEMBL308514 | 0.85 | ADORA2B (1.00) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A | |
| Acefylline SCHEMBL18191994 | 0.85 | ADORA2B (1.00) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A | |
| SCHEMBL11531219 | 0.85 | ADORA2B (0.78) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A | |
| Acefylline SCHEMBL8402147 | 0.84 | ADORA2B (0.97) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A | |
| SCHEMBL660023 | 0.84 | ADORA2B (0.76) | SMN1; SMN2ADORA2BLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4584372-A | Compound 3-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetyl-8-(2-phenylethyl)-1-oxa-3,8-diazaspiro-(4,5)decan-2-one and a process of preparation thereof | VENERO AURELIO O (ES) | 1986-04-22 | — | — | US | disclosed |