Acefylline

Acefylline

SCHEMBL308514

Cn1c(=O)c2c(ncn2CC(=O)O)n(C)c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 8/20 1.00
SMN1; SMN2 Q16637 3/20 0.72
LMNA P02545 3/20 0.68
MEN1 O00255 1/20 0.67
KMT2A Q03164 1/20 0.67
MAPT P10636 1/20 0.64
RXFP1 Q9HBX9 2/20 0.63
MAPK1 P28482 2/20 0.63
ALDH1A1 P00352 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acefylline SCHEMBL18191994 1.00 ADORA2B (1.00) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL8402147 0.98 ADORA2B (0.97) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL1173152 0.94 ADORA2B (0.89) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL356114 0.92 ADORA2B (0.85) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL5493561 0.92 ADORA2B (0.85) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
Acefylline SCHEMBL17204841 0.92 ADORA2B (0.84) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
SCHEMBL17163939 0.88 ADORA2B (0.78) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
SCHEMBL11531219 0.88 ADORA2B (0.78) ADORA2BSMN1; SMN2LMNAMEN1KMT2A
SCHEMBL9296212 0.87 ADORA2B (0.76) ADORA2BSMN1; SMN2LMNAKMT2AMAPT
SCHEMBL5468564 0.87 ADORA2B (0.76) ADORA2BSMN1; SMN2LMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1592 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025082655-A1 LOW WATER CONTENT W/O EMULSION COMPRISING A HYDROPHOBIC FILM-FORMING POLYMER, A LINEAR SILICONE POLYOL, HYALURONIC ACID, A VITAMIN B3 AND A XANTHINE BASE L'OREAL (FR) 2025-04-24 WO claimed
US-12128121-B2 Compositions comprising organo-silanol compounds, and applications EXSYMOL (MC) 2024-10-29 US claimed
EP-4153603-B1 COMPOSITIONS COMPRISING ORGANO-SILANOL COMPOUNDS, AND APPLICATIONS EXSYMOL SA (MC) 2023-11-01 EP claimed
US-20230181444-A1 COMPOSITIONS COMPRISING ORGANO-SILANOL COMPOUNDS, AND APPLICATIONS EXSYMOL (MC) 2023-06-15 US claimed
EP-4178948-A2 FUNCTIONALIZED ISONITRILES AND PRODUCTS, PREPARATION AND USES THEREOF Universidade de Santiago de Compostela (ES) 2023-05-17 EP claimed
EP-4153603-A1 COMPOSITIONS COMPRISING ORGANO-SILANOL COMPOUNDS, AND APPLICATIONS Exsymol (MC) 2023-03-29 EP claimed
CN-115275019-A Perovskite solar cell and preparation method thereof 宣城先进光伏技术有限公司 2022-11-01 CN claimed
CN-110974891-B Microneedle patch for losing weight and preparation method thereof 广州新济薇娜生物科技有限公司 2022-10-04 CN claimed
US-20220184052-A1 COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 US claimed
WO-2022123511-A1 A COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 WO claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0640342-A2 Pentoxifylline and/or depogen for improving the tissue antioxidant status CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1995-03-01 EP claimed
EP-0072286-B2 ORGANIC AMIDE COMPOUNDS DERIVED FROM NITROGENOUS LIPIDS FIDIA S.p.A. (IT) 1992-12-09 EP claimed
EP-0172383-B1 PHARMACOLOGICALLY ACTIVE SALT DERIVATIVES OF 1,2,3,6-TETRAHYDRO-1,3-DIMETHYL-2,6 DIOXOPURINE-7-ACETIC ACID LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A. (IT) 1992-02-05 EP claimed
US-4820838-A Process for the preparation of depogen CHINOIN GYOGYSZER- ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1989-04-11 US claimed
US-4654331-A Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group MERCK & CO., INC. (US) 1987-03-31 US claimed
EP-0072286-B1 ORGANIC AMIDE COMPOUNDS DERIVED FROM NITROGENOUS LIPIDS FIDIA S.p.A. (IT) 1986-10-29 EP claimed
US-4514404-A ANTITUSSIVE AGENTS PRODES, S.A. (ES) 1985-04-30 US claimed
EP-0051278-A1 Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same MERCK & CO. INC. (US) 1982-05-12 EP claimed
US-4071517-A Soluble salts containing sulphur DUFOUR CLAUDE 1978-01-31 US claimed