Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 5/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.69 |
| ▸ | TSHR | P16473 | 4/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HBB | P68871 | 1/20 | 0.64 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.63 |
| ▸ | PDE5A | O76074 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1085411 | 0.99 | ACP1 (0.87) | ACP1MAPK1TSHRALOX15TP53 | |
| SCHEMBL3460750 | 0.93 | ACP1 (0.74) | ACP1MAPK1TSHRALOX15TP53 | |
| SCHEMBL1085597 | 0.89 | ACP1 (0.87) | ACP1MAPK1TSHRALOX15TP53 | |
| SCHEMBL1085329 | 0.89 | ACP1 (0.69) | ACP1MAPK1TSHRALOX15TP53 | |
| SCHEMBL14259847 | 0.86 | ACP1 (0.69) | ACP1MAPK1TSHRALOX15TP53 | |
| SCHEMBL1091141 | 0.84 | TOP2A (0.64) | ACP1MAPK1TSHRALOX15USP2 | |
| SCHEMBL1084058 | 0.83 | CYP1A2 (0.65) | ACP1MAPK1TSHRALOX15TP53 | |
| SCHEMBL4089490 | 0.83 | TOP2A (0.63) | ACP1MAPK1TSHRALOX15USP2 | |
| SCHEMBL1090545 | 0.83 | TOP2A (0.67) | ACP1MAPK1TSHRALOX15MEN1 | |
| SCHEMBL3460217 | 0.82 | MAPK1 (0.61) | ACP1MAPK1TSHRALOX15TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-20100160316-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-24 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-20060217377-A1 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2006-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160316-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | KCNN3, KCNN2, CACNA1I | ACP1 4214/4885MAPK1 3922/4885TSHR 3915/4885 |
| US-20060217377-A1 | Quinazolines useful as modulators of ion channels | KCNN3, KCNN2, CACNA1I | ACP1 4214/4885MAPK1 3922/4885TSHR 3915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.