Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989636 | 0.89 | ALDH1A1 (0.67) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| SCHEMBL13462516 | 0.80 | ALDH1A1 (0.56) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| SCHEMBL15304957 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| SCHEMBL2646040 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| SCHEMBL10292257 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| SCHEMBL10850997 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| SCHEMBL2464280 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| SCHEMBL26686942 | 0.77 | TSHR (0.52) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| Hydrochloric Acid SCHEMBL9023424 | 0.77 | TSHR (0.52) | ALDH1A1TSHRNOS1HTR7CHRNB2 | |
| SCHEMBL8494349 | 0.77 | ALDH1A1 (0.52) | ALDH1A1TSHRNOS1HTR7CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567176-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-01-28 | — | — | US | disclosed |
| EP-0132914-A2 | Imidazolinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-02-13 | — | — | EP | disclosed |
| WO-1984004304-A1 | AMINOIMIDAZOLONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE FRENCH LAB (GB) | 1984-11-08 | — | — | WO | disclosed |