Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 4/20 | 0.54 |
| ▸ | TTR | P02766 | 6/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10861351 | 0.86 | TBXAS1 (0.54) | TBXAS1TTRTAAR1KDM4EALDH1A1 | |
| SCHEMBL10855599 | 0.84 | TAAR1 (0.42) | TBXAS1TTRTAAR1KDM4EALDH1A1 | |
| SCHEMBL10851678 | 0.78 | TAAR1 (0.38) | TBXAS1TAAR1HTR1A | |
| SCHEMBL10852177 | 0.74 | KDM4E (0.43) | TBXAS1TAAR1KDM4EALDH1A1GAA | |
| SCHEMBL11118554 | 0.74 | TAAR1 (0.47) | TBXAS1TAAR1KDM4EALDH1A1GAA | |
| SCHEMBL10861551 | 0.72 | TBXAS1 (0.54) | TBXAS1TAAR1KDM4EALDH1A1GAA | |
| SCHEMBL10856277 | 0.71 | ADRA2A (0.44) | TBXAS1TAAR1KDM4EALDH1A1GAA | |
| SCHEMBL10851831 | 0.70 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL28067592 | 0.70 | KDM4E (0.44) | TBXAS1TAAR1KDM4EALDH1A1GAA | |
| SCHEMBL10531244 | 0.69 | TAAR1 (0.50) | TBXAS1TAAR1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073663-B1 | THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Limited (GB) | 1986-06-18 | — | — | EP | disclosed |
| US-4590200-A | NON-INHIBITION OF PROSTACYCLIN SYNTHETASE OR CYCLO-OXYGENASE | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0073663-A2 | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them | Pfizer Limited (GB) | 1983-03-09 | — | — | EP | disclosed |