Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 9/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28117285 | 0.87 | MAPT (0.51) | FFAR4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL2074825 | 0.84 | SLC2A1 (0.52) | MAPTMAPK1TDP1L3MBTL1TTR | |
| SCHEMBL14573028 | 0.83 | FFAR4 (0.67) | FFAR4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL6672350 | 0.82 | TTR (0.60) | MAPK1RXRATTRHTTSMN1; SMN2 | |
| SCHEMBL5387584 | 0.82 | TTR (0.65) | MAPTTTRSMN1; SMN2 | |
| SCHEMBL13144443 | 0.81 | MRGPRX4 (0.68) | FFAR4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL8624168 | 0.81 | RXRA (0.61) | FFAR4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL2880445 | 0.81 | MRGPRX4 (0.66) | FFAR4MAPTMAPK1TDP1L3MBTL1 | |
| Phosphine SCHEMBL4434544 | 0.81 | TTR (0.59) | MAPK1RXRATTRHTTSMN1; SMN2 | |
| SCHEMBL4704085 | 0.81 | FFAR4 (0.63) | FFAR4MAPTMAPK1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4582847-A | 4-chloro-2-phenylimidazole-5-acetic acid derivatives and use as diuretics and hypotensives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-04-15 | — | — | US | disclosed |
| EP-0103647-A1 | 4-CHLORO-2-PHENYLIMIDAZOLE-5-ACETIC ACID DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1984-03-28 | — | — | EP | disclosed |