Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | CMA1 | P23946 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10859920 | 0.88 | KDM4E (0.43) | ALDH1A1KDM4ETBXAS1GPR84HTT | |
| SCHEMBL10859507 | 0.80 | HCRTR1 (0.46) | ALDH1A1KDM4ETBXAS1GAASMN1; SMN2 | |
| SCHEMBL10861551 | 0.79 | TBXAS1 (0.54) | ALDH1A1KDM4ETBXAS1GAASMN1; SMN2 | |
| SCHEMBL10851538 | 0.78 | KDM4E (0.45) | ALDH1A1KDM4ETBXAS1HTTGAA | |
| SCHEMBL149468 | 0.76 | TBXAS1 (0.54) | ALDH1A1KDM4ETBXAS1HTTGAA | |
| SCHEMBL10858401 | 0.76 | TBXAS1 (0.44) | ALDH1A1KDM4ETBXAS1GAASMN1; SMN2 | |
| SCHEMBL10860476 | 0.76 | TBXAS1 (0.39) | ALDH1A1KDM4ETBXAS1HTTGAA | |
| Hydrochloric Acid SCHEMBL10853856 | 0.76 | TBXAS1 (0.53) | ALDH1A1KDM4ETBXAS1HTTGAA | |
| SCHEMBL6746541 | 0.73 | ALDH1A1 (0.60) | ALDH1A1KDM4EHTTGAASMN1; SMN2 | |
| SCHEMBL10953653 | 0.72 | ROCK1 (0.45) | ALDH1A1KDM4ETBXAS1HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073663-B1 | THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Limited (GB) | 1986-06-18 | — | — | EP | disclosed |
| US-4590200-A | NON-INHIBITION OF PROSTACYCLIN SYNTHETASE OR CYCLO-OXYGENASE | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0073663-A2 | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them | Pfizer Limited (GB) | 1983-03-09 | — | — | EP | disclosed |