Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.75 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.75 |
| ▸ | DRD3 | P35462 | 2/20 | 0.75 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.75 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.71 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | MITF | O75030 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.66 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10885813 | 0.98 | ALDH1A1 (0.76) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL9170851 | 0.98 | ALDH1A1 (0.73) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL10849479 | 0.91 | CHRM2 (0.72) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL4516510 | 0.86 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL21451092 | 0.86 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL4780118 | 0.86 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL10852535 | 0.86 | CHRM2 (0.78) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL148499 | 0.86 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL17223884 | 0.86 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL10584214 | 0.84 | ALDH1A1 (0.97) | CHRM2ADRA2BDRD3SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4181803-A | 4'-SUBSTITUTED-2-METHYL-3-PIPERIDINO-PROPIOPHENONES; ANTISPASMODIC AGENTS, MUSCLE RELAXANTS | EISAI CO., LTD. (JP) | 1980-01-01 | — | — | US | claimed |
| US-3995047-A | Propiophenone derivatives in the treatment of pathological muscular conditions | EISAI CO., LTD. (JA) | 1976-11-30 | — | — | US | claimed |
| US-4563454-A | ASTHMA, RHINITIS, DERMATITIS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1986-01-07 | — | — | US | disclosed |
| US-4277474-A | DERMATITIS, RHINITIS, ASTHMA | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1981-07-07 | — | — | US | disclosed |
| US-4181803-A | 4'-SUBSTITUTED-2-METHYL-3-PIPERIDINO-PROPIOPHENONES; ANTISPASMODIC AGENTS, MUSCLE RELAXANTS | EISAI CO., LTD. (JP) | 1980-01-01 | — | — | US | disclosed |
| EP-0004000-A1 | New propanone derivatives, process for producing thereof and pharmaceutical compositions containing these derivatives as active ingredients | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1979-09-19 | — | — | EP | disclosed |
| US-3995047-A | Propiophenone derivatives in the treatment of pathological muscular conditions | EISAI CO., LTD. (JA) | 1976-11-30 | — | — | US | disclosed |