Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.35 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.35 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10756747 | 0.87 | KDM4C (0.43) | KDM4CSMN1; SMN2CES2CES1PTPN7 | |
| SCHEMBL14868475 | 0.85 | SMN1; SMN2 (0.39) | KDM4CSMN1; SMN2CES2CES1KDM4E | |
| SCHEMBL10852760 | 0.80 | SMN1; SMN2 (0.49) | KDM4CSMN1; SMN2CES2CES1PTPN7 | |
| SCHEMBL9547521 | 0.78 | SMN1; SMN2 (0.56) | KDM4CSMN1; SMN2CES2CES1PTPN7 | |
| SCHEMBL10756983 | 0.78 | KDM4C (0.41) | KDM4CSMN1; SMN2ALDH1A1KDM4ERAB9A | |
| SCHEMBL10759580 | 0.78 | RAB9A (0.47) | KDM4CSMN1; SMN2PTPN7ALDH1A1RAB9A | |
| SCHEMBL10753511 | 0.77 | GLA (0.47) | KDM4CSMN1; SMN2ALDH1A1KDM4ERAB9A | |
| SCHEMBL10757205 | 0.76 | GAA (0.45) | KDM4CSMN1; SMN2ALDH1A1KDM4ERAB9A | |
| SCHEMBL10754708 | 0.75 | PTPN7 (0.43) | KDM4CSMN1; SMN2PTPN7ALDH1A1RAB9A | |
| SCHEMBL10758718 | 0.75 | RAB9A (0.43) | KDM4CSMN1; SMN2ALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4565826-A | HYPOTENSIVE, CARDIONASCULAR, ANTIULCER, ANTISECRETORY, GASTROINTESTINAL DISORDERS | WILLIAM H. RORER, INC. (US) | 1986-01-21 | — | — | US | disclosed |
| US-4436911-A | HYPOTENSIVE, ANTISPASMODIC, ANTIULCER, ANTIPARASITIC | WILLIAM H. RORER, INC. (US) | 1984-03-13 | — | — | US | disclosed |