Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 12/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145411 | 0.91 | TBXAS1 (0.56) | TBXAS1CSNK2A1 | |
| SCHEMBL10851841 | 0.81 | TBXAS1 (0.46) | TBXAS1HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10859377 | 0.81 | PTGFR (0.39) | TBXAS1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10953675 | 0.78 | TBXAS1 (0.57) | TBXAS1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10854472 | 0.78 | AR (0.41) | HPGDCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8595302 | 0.76 | CLK1 (0.41) | TBXAS1NAPRT | |
| SCHEMBL10855300 | 0.74 | TBXAS1 (0.54) | TBXAS1HPGD | |
| SCHEMBL10531061 | 0.74 | TBXAS1 (0.53) | TBXAS1CSNK2A1NAPRT | |
| SCHEMBL10859386 | 0.73 | HTT (0.42) | TBXAS1CYP1A2CYP3A4CYP2C9PKM | |
| SCHEMBL10852442 | 0.72 | TBXAS1 (0.54) | TBXAS1CSNK2A1NAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073663-B1 | THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Limited (GB) | 1986-06-18 | — | — | EP | disclosed |
| US-4590200-A | NON-INHIBITION OF PROSTACYCLIN SYNTHETASE OR CYCLO-OXYGENASE | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0073663-A2 | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them | Pfizer Limited (GB) | 1983-03-09 | — | — | EP | disclosed |