Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28911945 | 0.85 | PRCP (0.35) | PRCPDPP7TLR2 | |
| SCHEMBL675798 | 0.85 | PRCP (0.35) | PRCPDPP7TLR2 | |
| SCHEMBL333102 | 0.85 | PRCP (0.35) | PRCPDPP7TLR2 | |
| SCHEMBL2706462 | 0.85 | PRCP (0.35) | PRCPDPP7TLR2 | |
| SCHEMBL2422874 | 0.85 | PRCP (0.35) | PRCPDPP7TLR2 | |
| SCHEMBL11557434 | 0.84 | REN (0.35) | PRCPDPP7CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL11559061 | 0.84 | PRCP (0.35) | PRCPDPP7CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL11559258 | 0.82 | NOS2 (0.38) | PRCPDPP7CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL7377621 | 0.82 | DPP7 (0.36) | PRCPDPP7CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL9592134 | 0.82 | NOS2 (0.37) | PRCPDPP7CYP3A4CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035336-B1 | NOVEL PROCESSES FOR PREPARING PROLINE DERIVATIVES AND ANALOGOUS COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1986-04-09 | — | — | EP | disclosed |
| US-4578480-A | ANGIOTENSIN CONVERTING ENZYME INHUBITOR INTERMEDIATES | JOHN WYETH & BROTHER LIMITED (GB) | 1986-03-25 | — | — | US | disclosed |
| US-4506082-A | DEESTERIFICATION WITH TRIFLUOROACETIC ACID | JOHN WYETH & BROTHER LIMITED (GB) | 1985-03-19 | — | — | US | disclosed |
| US-4391752-A | Process for preparing 5H-pyrrolo[2,1-c]-[1,4]thiazepine-1,5-diones | JOHN WYETH AND BROTHER LIMITED (GB) | 1983-07-05 | — | — | US | disclosed |
| US-4349480-A | Process for preparing 1-(3-bromo-2-alkylpropanoyl-L-proline derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1982-09-14 | — | — | US | disclosed |
| EP-0035336-A2 | Novel processes for preparing proline derivatives and analogous compounds | JOHN WYETH & BROTHER LIMITED (GB) | 1981-09-09 | — | — | EP | disclosed |
| US-4181663-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1980-01-01 | — | — | US | disclosed |