Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10808165 | 0.91 | TP53 (0.39) | TP53ABCB1ABCG2SLC6A4KDM4E | |
| SCHEMBL10818661 | 0.90 | ABCB1 (0.39) | TP53ABCB1ABCG2SLC6A4KDM4E | |
| SCHEMBL10815996 | 0.90 | ABCB1 (0.39) | ABCB1ABCG2SLC6A4KDM4EMTNR1B | |
| SCHEMBL11105995 | 0.88 | TP53 (0.39) | TP53ABCB1ABCG2SLC6A4KDM4E | |
| SCHEMBL11113912 | 0.82 | EGFR (0.41) | TP53ABCB1ABCG2SLC6A4KDM4E | |
| SCHEMBL11112919 | 0.81 | ABCB1 (0.36) | ABCB1ABCG2SLC6A4KDM4EMTNR1B | |
| SCHEMBL10804503 | 0.81 | ABCB1 (0.40) | ABCB1ABCG2SLC6A4KDM4EMTNR1B | |
| SCHEMBL10854756 | 0.81 | ABCB1 (0.40) | TP53ABCB1ABCG2SLC6A4KDM4E | |
| SCHEMBL10817766 | 0.80 | KDM4E (0.57) | TP53ABCB1ABCG2KDM4ERAB9A | |
| SCHEMBL10851137 | 0.79 | HTR5A (0.40) | ABCB1ABCG2SLC6A4KDM4EMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4575508-A | 2-Substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-β-carbolines, and their use as antiarrhythmic agents | BASF AKTIENGESELLSCHAFT (DE) | 1986-03-11 | — | — | US | disclosed |