Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475931 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11023795 | 0.87 | KDM4E (0.46) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11020327 | 0.86 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11024081 | 0.85 | KDM4E (0.44) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11020026 | 0.82 | KDM4E (0.42) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL10856397 | 0.82 | PDE3B (0.46) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11023105 | 0.81 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11023389 | 0.81 | KDM4E (0.41) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL11023139 | 0.80 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDGAAGALR3 | |
| SCHEMBL10851773 | 0.80 | PDE3B (0.48) | KDM4EALDH1A1HPGDGAAPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154190-A1 | Pyridones | MERCK PATENT GmbH (DE) | 1985-09-11 | — | — | EP | claimed |
| US-4595762-A | 5-α-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles | STERLING DRUG INC. (US) | 1986-06-17 | — | — | US | disclosed |
| EP-0154190-A1 | Pyridones | MERCK PATENT GmbH (DE) | 1985-09-11 | — | — | EP | disclosed |
| US-4539327-A | 5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-09-03 | — | — | US | disclosed |
| US-4469699-A | 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1984-09-04 | — | — | US | disclosed |