Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10855374 | 0.85 | TAAR1 (0.40) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10854905 | 0.81 | TAAR1 (0.38) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10855300 | 0.81 | TBXAS1 (0.54) | TAAR1HTR1ATBXAS1 | |
| SCHEMBL149468 | 0.73 | TBXAS1 (0.54) | TAAR1HTR1ATBXAS1 | |
| SCHEMBL11168704 | 0.73 | TBXAS1 (0.41) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL10853856 | 0.72 | TBXAS1 (0.53) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10859377 | 0.72 | PTGFR (0.39) | FPR2TBXAS1 | |
| SCHEMBL10858277 | 0.71 | TBXAS1 (0.36) | TBXAS1 | |
| SCHEMBL10859530 | 0.71 | TBXAS1 (0.33) | TBXAS1 | |
| SCHEMBL10853085 | 0.71 | ADRA2A (0.48) | TAAR1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073663-B1 | THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Limited (GB) | 1986-06-18 | — | — | EP | disclosed |
| US-4590200-A | NON-INHIBITION OF PROSTACYCLIN SYNTHETASE OR CYCLO-OXYGENASE | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0073663-A2 | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them | Pfizer Limited (GB) | 1983-03-09 | — | — | EP | disclosed |