Pyrazine

Pyrazine

SCHEMBL1086211

c1cnccn1.c1csc(-c2ccsc2-c2cccs2)c1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2E1 P05181 1/20 0.46
CYP2A6 P11509 1/20 0.46
CYP2B6 P20813 1/20 0.46
KDM4E B2RXH2 5/20 0.41
ALDH1A1 P00352 4/20 0.41
HPGD P15428 4/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
MAPT P10636 3/20 0.41
TDP1 Q9NUW8 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
CYP17A1 P05093 1/20 0.41
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
TDO2 P48775 1/20 0.41
POLB P06746 1/20 0.40
MAPK14 Q16539 1/20 0.40
NISCH Q9Y2I1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL365802 0.92 KDM4E (0.42) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL147273 0.92 KDM4E (0.42) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL22734807 0.88 PTPRC (0.41) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL22763791 0.88 PTPRC (0.41) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL22734772 0.88 PTPRC (0.41) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL22763310 0.88 PTPRC (0.41) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
SCHEMBL22734786 0.88 PTPRC (0.41) CYP3A4CYP2C9CYP2E1CYP2A6CYP2B6
Methyl Alcohol SCHEMBL6013731 0.86 ALDH1A1 (0.42) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL5050633 0.86 LTA4H (0.44) KDM4EALDH1A1HPGDMEN1KMT2A
Boric Acid SCHEMBL1568788 0.84 ALDH1A1 (0.41) KDM4EALDH1A1HPGDMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8154787-B2 Electrochromic materials UNIVERSITY OF WASHINGTON (US) 2012-04-10 US disclosed
US-20100324306-A1 ELECTROCHROMIC MATERIALS UNIVERSITY OF WASHINGTON (US) 2010-12-23 US disclosed
US-7808691-B2 transparent electrode, polymer based on fluorinated derivative of (2,3-Di-thiophen-2-yl-thieno[3,4-b]pyrazine), and electrolyte; single absorption band UNIVERSITY OF WASHINGTON (US) 2010-10-05 US disclosed
US-20090067030-A1 SYNTHESIS OF GREEN ELECTROCHROMIC MATERIALS UNIVERSITY OF WASHINGTON (US) 2009-03-12 US disclosed
US-7298541-B2 Green electrochromic (EC) material and device UNIVERSITY OF WASHINGTON (US) 2007-11-20 US disclosed
US-20070177243-A1 Green electrochromic (EC) material and device UNIVERSITY OF WASHINGTON (US) 2007-08-02 US disclosed
EP-1784686-A2 GREEN ELECTROCHROMIC (EC) MATERIAL AND DEVICE University of Washington (US) 2007-05-16 EP disclosed
WO-2006029344-A2 GREEN ELECTROCHROMIC (EC) MATERIAL AND DEVICE UNIVERSITY OF WASHINGTON (US) 2006-03-16 WO disclosed