Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.74 |
| ▸ | PDE4A | P27815 | 15/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroximone SCHEMBL119758 | 0.85 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7434326 | 0.81 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10876599 | 0.80 | PDE3B (0.73) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10876292 | 0.79 | PDE3B (0.72) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7446222 | 0.79 | PDE3B (0.72) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10502059 | 0.77 | POLB (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7431570 | 0.76 | PDE3B (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7430671 | 0.76 | PDE3B (0.67) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10635371 | 0.75 | PDE3B (0.55) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7430633 | 0.73 | PDE3B (0.41) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170214-A1 | The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-05 | — | — | EP | disclosed |