Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 5/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | APLNR | P35414 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440629 | 0.87 | PDE3B (0.59) | POLBPDE3BPDE3APDE4APDE4B | |
| SCHEMBL7430633 | 0.80 | PDE3B (0.41) | POLBPDE3BPDE3APDE4APDE4B | |
| SCHEMBL10864124 | 0.77 | PDE3B (0.74) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7440527 | 0.75 | NFKB1 (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7434326 | 0.72 | PDE3B (0.49) | POLBPDE3BPDE3APDE4APDE4B | |
| SCHEMBL10502325 | 0.71 | POLB (0.38) | POLBKMT2ASMN1; SMN2APLNRKDM4E | |
| Alcohol SCHEMBL9405122 | 0.69 | KMT2A (0.62) | KMT2ALMNAHTTSMN1; SMN2KDM4E | |
| Propylamine SCHEMBL28734534 | 0.68 | KMT2A (0.56) | KMT2ALMNAHTTSMN1; SMN2KDM4E | |
| SCHEMBL7434015 | 0.68 | PDE3B (0.56) | POLBPDE3BPDE3APDE4APDE4B | |
| SCHEMBL7425415 | 0.67 | PDE3B (0.58) | POLBPDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170214-B1 | THE PREPARATION OF 1,3-DIHYDRO-4-PYRIDOYL-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-13 | — | — | EP | disclosed |
| EP-0170214-A1 | The preparation of 1,3-Dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-05 | — | — | EP | disclosed |