Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 4/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10905704 | 0.88 | KMT2A (0.40) | KMT2ACDK2PARP1ATG4BRAD52 | |
| SCHEMBL11838515 | 0.85 | KMT2A (0.38) | KMT2ACDK2PARP1ATG4BRAD52 | |
| SCHEMBL21104441 | 0.84 | CDK2 (0.47) | KMT2ACDK2PARP1ATG4BRAD52 | |
| SCHEMBL16116423 | 0.82 | PARP1 (0.59) | KMT2APARP1ATG4BNSD2CASP6 | |
| SCHEMBL11318564 | 0.79 | KMT2A (0.45) | KMT2ACDK2PARP1RAD52GAA | |
| SCHEMBL11403548 | 0.79 | CDK2 (0.46) | KMT2ACDK2PARP1ATG4BALDH1A1 | |
| SCHEMBL24317500 | 0.76 | CDK2 (0.44) | KMT2ACDK2PARP1ATG4BRAD52 | |
| SCHEMBL7936537 | 0.76 | RAD52 (0.44) | KMT2APARP1RAD52GAAMAPT | |
| SCHEMBL29532490 | 0.75 | MAPT (0.43) | KMT2ACDK2PARP1GAAMAPT | |
| SCHEMBL24317498 | 0.75 | MAPT (0.43) | KMT2ACDK2PARP1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0185240-A2 | Process for the preparation of N-substituted benz[c,d]indol-2-ones | BAYER AG (DE) | 1986-06-25 | — | — | EP | disclosed |
| EP-0167821-A1 | Process for carrying out Friedel-Crafts and Friedel-Crafts-like reactions | BAYER AG (DE) | 1986-01-15 | — | — | EP | disclosed |
| US-4529804-A | Naphthostyril Ni or Cu complexes, a process for their preparation, and high molecular weight organic material pigmented with these metal complexes | CIBA-GEIGY CORPORATION (US) | 1985-07-16 | — | — | US | disclosed |