Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10865051 | 0.99 | DRD4 (0.48) | HTR1AHTR7DRD4DRD2HTR2A | |
| SCHEMBL10863098 | 0.97 | THRA (0.47) | HTR1AHTR7DRD4DRD2HTR2A | |
| SCHEMBL10863523 | 0.88 | HTR1A (0.50) | HTR1AHTR7DRD4DRD2HTR2A | |
| SCHEMBL10864609 | 0.87 | DRD4 (0.49) | HTR1AHTR7DRD4DRD2HTR2A | |
| SCHEMBL10864507 | 0.87 | HTR1A (0.45) | HTR1AHTR7DRD4DRD2HTR2A | |
| SCHEMBL10864514 | 0.87 | DRD4 (0.52) | HTR1ADRD4DRD2GAA | |
| SCHEMBL10865808 | 0.87 | HTR1A (0.48) | HTR1AHTR7DRD4DRD2HTR2A | |
| SCHEMBL10863236 | 0.86 | HTR1A (0.48) | HTR1AHTR7DRD4DRD2HTR2A | |
| SCHEMBL10864154 | 0.86 | DRD4 (0.45) | HTR1AHTR7DRD4DRD2HTR2A | |
| SCHEMBL10865638 | 0.86 | DRD4 (0.53) | HTR1ADRD4DRD2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4613598-A | HYPOTENSIVE AGENTS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1986-09-23 | — | — | US | disclosed |
| EP-0154969-A2 | Piperazine derivatives and their acid addition salts | MITSUBISHI KASEI CORPORATION (JP) | 1985-09-18 | — | — | EP | disclosed |