Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 12/20 | 0.40 |
| ▸ | REN | P00797 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PEPD | P12955 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | GRB2 | P62993 | 1/20 | 0.37 |
| ▸ | XPNPEP2 | O43895 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30974453 | 0.89 | ACE (0.40) | ACERENLMNAKDM4EF2 | |
| Arginine SCHEMBL7265626 | 0.87 | ACE (0.38) | ACERENLMNAKDM4EF2 | |
| Arginine SCHEMBL7270511 | 0.87 | ACE (0.38) | ACERENLMNAKDM4EF2 | |
| Arginine SCHEMBL10656209 | 0.87 | ACE (0.44) | ACELMNAACE2 | |
| SCHEMBL7272757 | 0.86 | ACE (0.43) | ACERENLMNAKDM4EF2 | |
| SCHEMBL11037632 | 0.86 | ACE (0.43) | ACERENLMNAKDM4EF2 | |
| Arginine SCHEMBL10653944 | 0.86 | ACE (0.51) | ACELMNA | |
| Arginine SCHEMBL10654662 | 0.86 | ACE (0.43) | ACELMNAACE2 | |
| SCHEMBL30167875 | 0.85 | CAPN1 (0.38) | ACEREN | |
| Arginine SCHEMBL7263651 | 0.85 | DPP4 (0.46) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173510-A2 | Tripeptide derivatives for use as anti-hypertensive agents | AJINOMOTO CO., INC. (JP) | 1986-03-05 | — | — | EP | disclosed |