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Arginine

Arginine

SCHEMBL10653944

C[C@H](NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ ACE known ✓ P12821 10/20 0.51
▸ LMNA P02545 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL10653999 0.87 PREP (0.51) ACELMNASMN1; SMN2
Arginine SCHEMBL10654400 0.87 ACE (0.46) ACELMNASMN1; SMN2
Arginine SCHEMBL10656209 0.86 ACE (0.44) ACELMNASMN1; SMN2
Arginine SCHEMBL10866875 0.86 ACE (0.40) ACELMNA
Arginine SCHEMBL10658646 0.85 ACE (0.47) ACELMNASMN1; SMN2
Arginine SCHEMBL7263661 0.85 ACE (0.47) ACELMNASMN1; SMN2
Arginine SCHEMBL10654662 0.85 ACE (0.43) ACELMNASMN1; SMN2
Arginine SCHEMBL7264429 0.85 ACE (0.47) ACELMNASMN1; SMN2
SCHEMBL10659600 0.85 ACE (0.62) ACELMNASMN1; SMN2
SCHEMBL9814474 0.81 ACE (0.67) ACELMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4719200-A Amino acid derivatives and antihypertensive drugs containing the same AJINOMOTO CO., INC. (JP) 1988-01-12 — — US disclosed
EP-0173510-A2 Tripeptide derivatives for use as anti-hypertensive agents AJINOMOTO CO., INC. (JP) 1986-03-05 — — EP disclosed
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