Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL10654662 | 0.92 | ACE (0.43) | ACELMNAFKBP1ASMN1; SMN2MMP1 | |
| Arginine SCHEMBL10866875 | 0.87 | ACE (0.40) | ACELMNAACE2 | |
| Arginine SCHEMBL10653944 | 0.86 | ACE (0.51) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL10653999 | 0.86 | PREP (0.51) | ACELMNASMN1; SMN2ACE2 | |
| Arginine SCHEMBL10654400 | 0.85 | ACE (0.46) | ACELMNASMN1; SMN2ACE2 | |
| Arginine SCHEMBL10658646 | 0.83 | ACE (0.47) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL7264429 | 0.83 | ACE (0.47) | ACELMNASMN1; SMN2 | |
| Arginine SCHEMBL7263661 | 0.83 | ACE (0.47) | ACELMNASMN1; SMN2 | |
| SCHEMBL10656626 | 0.83 | ACE (0.52) | ACELMNADGAT1ACE2 | |
| SCHEMBL30974453 | 0.82 | ACE (0.40) | ACELMNAACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4719200-A | Amino acid derivatives and antihypertensive drugs containing the same | AJINOMOTO CO., INC. (JP) | 1988-01-12 | — | — | US | disclosed |
| EP-0173510-A2 | Tripeptide derivatives for use as anti-hypertensive agents | AJINOMOTO CO., INC. (JP) | 1986-03-05 | — | — | EP | disclosed |