Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CASP6 | P55212 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | KIF11 | P52732 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GPR3 | P46089 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 1/20 | 0.49 |
| ▸ | GABRD | O14764 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30227209 | 0.92 | AHR (0.64) | KMT2AMEN1POLBGAACASP6 | |
| SCHEMBL150279 | 0.92 | AHR (0.64) | KMT2AMEN1POLBGAACASP6 | |
| SCHEMBL28022470 | 0.92 | AHR (0.64) | KMT2AMEN1POLBGAACASP6 | |
| Potassium SCHEMBL10868617 | 0.90 | AHR (0.61) | KMT2AMEN1POLBGAACASP6 | |
| Bicarbonate SCHEMBL10867986 | 0.89 | MEN1 (0.56) | KMT2AMEN1POLBGAACASP6 | |
| Bicarbonate SCHEMBL10868532 | 0.89 | MEN1 (0.56) | KMT2AMEN1POLBGAACASP6 | |
| SCHEMBL9709209 | 0.85 | GAA (0.80) | KMT2AMEN1POLBGAACASP6 | |
| Carbazole SCHEMBL8411559 | 0.84 | ALDH1A1 (0.74) | KMT2AMEN1POLBGAATDP1 | |
| SCHEMBL124178 | 0.82 | KDM4E (0.57) | KMT2AMEN1POLBGAACASP6 | |
| SCHEMBL29365550 | 0.82 | KDM4E (0.57) | KMT2AMEN1POLBGAACASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181546-A1 | Process for the preparation of 2-hydroxy-carbozole-1-carboxylic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-05-21 | — | — | EP | claimed |
| EP-0181546-A1 | Process for the preparation of 2-hydroxy-carbozole-1-carboxylic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-05-21 | — | — | EP | disclosed |
| EP-0110239-A1 | Process for the preparation of 2-hydroxy-carbazole-1-carboxylic acid | BAYER AG (DE) | 1984-06-13 | — | — | EP | disclosed |