Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 7/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10875135 | 0.90 | PDE3B (0.47) | PDE3BPDE3AMAPTL3MBTL1LMNA | |
| SCHEMBL10877977 | 0.85 | PDE3B (0.46) | PDE3BPDE3AMAPTL3MBTL1LMNA | |
| SCHEMBL10877366 | 0.83 | PDE3B (0.49) | PDE3BPDE3AMAPTL3MBTL1LMNA | |
| SCHEMBL10876859 | 0.82 | PDE3B (0.65) | PDE3BPDE3AMAPTLMNAPDE4A | |
| SCHEMBL10877206 | 0.81 | NPC1 (0.50) | PDE3BPDE3AMAPTL3MBTL1LMNA | |
| SCHEMBL10950631 | 0.80 | PDE3B (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10877786 | 0.79 | PDE3B (0.50) | PDE3BPDE3AMAPTLMNAPDE4A | |
| SCHEMBL10875411 | 0.79 | PDE3B (0.45) | PDE3BPDE3AMAPTL3MBTL1LMNA | |
| SCHEMBL10950776 | 0.79 | PDE3B (0.45) | PDE3BPDE3AMAPTL3MBTL1LMNA | |
| SCHEMBL10880137 | 0.78 | PDE3B (0.49) | PDE3BPDE3AMAPTLMNAPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065165-B1 | 5-OXYMETHYL-4-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| US-4526981-A | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-02 | — | — | US | disclosed |
| EP-0065165-A1 | 5-Oxymethyl-4-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-24 | — | — | EP | disclosed |