Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 7/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10950769 | 0.90 | PDE3B (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10877366 | 0.87 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10877977 | 0.83 | PDE3B (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10877786 | 0.82 | PDE3B (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10876859 | 0.82 | PDE3B (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10875411 | 0.82 | PDE3B (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10880137 | 0.81 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10875135 | 0.81 | PDE3B (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10875726 | 0.79 | PDE3B (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10877206 | 0.79 | NPC1 (0.50) | PDE3BPDE3ARAB9ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4526981-A | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-02 | — | — | US | disclosed |