Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877977 | 0.85 | PDE3B (0.46) | NPC1RAB9AESR2ALDH1A1LMNA | |
| SCHEMBL10877366 | 0.83 | PDE3B (0.49) | NPC1RAB9AESR2ALDH1A1LMNA | |
| SCHEMBL10876870 | 0.83 | NPC1 (0.47) | NPC1RAB9AALDH1A1KDM4EMMP1 | |
| SCHEMBL10875135 | 0.83 | PDE3B (0.47) | NPC1RAB9AESR2LMNARXFP1 | |
| SCHEMBL10875726 | 0.81 | PDE3B (0.45) | NPC1RAB9AESR2LMNAL3MBTL1 | |
| SCHEMBL10876464 | 0.81 | PDE3B (0.51) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL10877786 | 0.79 | PDE3B (0.50) | RAB9AALDH1A1LMNARXFP1CES2 | |
| SCHEMBL10876859 | 0.79 | PDE3B (0.65) | RAB9AALDH1A1LMNARXFP1CES2 | |
| SCHEMBL10875411 | 0.79 | PDE3B (0.45) | NPC1RAB9AESR2ALDH1A1LMNA | |
| SCHEMBL10950776 | 0.79 | PDE3B (0.45) | NPC1RAB9AESR2LMNAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065165-B1 | 5-OXYMETHYL-4-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |