Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 3/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | BAX | Q07812 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4345160 | 0.88 | SOS1 (0.65) | SOS1MEN1KMT2AHSP90AA1MAPK1 | |
| SCHEMBL14662201 | 0.82 | SOS1 (0.60) | SOS1LTA4HNR1H2BAXHTR2A | |
| SCHEMBL10354980 | 0.82 | HSP90AA1 (0.74) | MEN1KMT2AESR1ESR2HSP90AA1 | |
| SCHEMBL31287790 | 0.82 | HSP90AA1 (0.74) | MEN1KMT2AESR1ESR2HSP90AA1 | |
| SCHEMBL10355136 | 0.82 | ESR1 (0.61) | SOS1MEN1KMT2AESR1ESR2 | |
| SCHEMBL1979103 | 0.81 | SOS1 (0.63) | SOS1MEN1KMT2AMAPK1HTR2A | |
| SCHEMBL26601050 | 0.81 | SOS1 (0.58) | SOS1HSP90AA1HTR2ASLC6A4KCNH2 | |
| SCHEMBL10875782 | 0.81 | SOS1 (0.58) | SOS1MEN1KMT2ALTA4HHTR2A | |
| SCHEMBL14656127 | 0.80 | SOS1 (0.54) | SOS1MEN1KMT2AHSP90AA1MAPK1 | |
| SCHEMBL9623378 | 0.80 | ESR1 (0.58) | MEN1KMT2AESR1ESR2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4625048-A | PESTICIDES | HOFFMANN-LA ROCHE INC. (US) | 1986-11-25 | — | — | US | disclosed |
| EP-0072475-B1 | CARBAMIC ESTERS, PREPARATION THEREOF, PESTICIDAL COMPOSITIONS ON THE BASIS OF THESE COMPOUNDS AND THEIR USE IN COMBATING PESTS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-08-20 | — | — | EP | disclosed |
| EP-0072475-A2 | Carbamic esters, preparation thereof, pesticidal compositions on the basis of these compounds and their use in combating pests | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-02-23 | — | — | EP | disclosed |