Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877366 | 0.83 | PDE3B (0.49) | NPC1RAB9AMAPTPDE3BPDE3A | |
| SCHEMBL10877206 | 0.83 | NPC1 (0.50) | NPC1RAB9AACHEMAPTBRD4 | |
| SCHEMBL10877977 | 0.80 | PDE3B (0.46) | NPC1RAB9AMAPTPDE3BPDE3A | |
| SCHEMBL10950631 | 0.80 | PDE3B (0.44) | PDE3BPDE3ASMN1; SMN2PLA2G4B | |
| SCHEMBL10876859 | 0.79 | PDE3B (0.65) | RAB9AMAPTPDE3BPDE3ACES2 | |
| SCHEMBL10877786 | 0.79 | PDE3B (0.50) | RAB9AMAPTPDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL10875411 | 0.79 | PDE3B (0.45) | NPC1RAB9AMAPTPDE3BPDE3A | |
| SCHEMBL10950776 | 0.79 | PDE3B (0.45) | NPC1RAB9AMAPTPDE3BPDE3A | |
| SCHEMBL10874712 | 0.78 | PDE3B (0.52) | NPC1RAB9AMAPTELANEPDE3B | |
| SCHEMBL10880137 | 0.78 | PDE3B (0.49) | RAB9AMAPTBRD4PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065165-B1 | 5-OXYMETHYL-4-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| EP-0065165-A1 | 5-Oxymethyl-4-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-24 | — | — | EP | disclosed |