Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 8/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | FABP2 | P12104 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877453 | 0.85 | PTGS1 (0.39) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL11015357 | 0.80 | AKR1B1 (0.33) | AKR1C3AKR1C2AKR1B1 | |
| SCHEMBL11012237 | 0.76 | PTGS2 (0.41) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL9405212 | 0.74 | AKT1 (0.41) | AKR1C3AKR1C2PTGS2PTGS1CYP2C19 | |
| SCHEMBL10879109 | 0.69 | AKR1C3 (0.39) | AKR1C3AKR1C2PTGS2PTGS1CYP2C19 | |
| SCHEMBL298241 | 0.66 | AKR1C3 (0.53) | AKR1C3AKR1C2PTGS2PTGS1CYP2C19 | |
| SCHEMBL11013390 | 0.65 | HDAC4 (0.45) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL2162196 | 0.65 | AKR1C3 (0.51) | AKR1C3AKR1C2PTGS2PTGS1CYP2C19 | |
| SCHEMBL11200807 | 0.63 | PTGS1 (0.39) | AKR1C3AKR1C2PTGS2PTGS1MEN1 | |
| SCHEMBL2125873 | 0.62 | PTGS2 (0.54) | AKR1C3AKR1C2PTGS2PTGS1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0083222-B1 | NEW QUINOLYLACETIC ACID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1986-02-26 | — | — | EP | claimed |
| US-4555513-A | 1,2 Dihydro- and 1,2,3,4-tetrahydro quinolylacetic acids and analgesic use thereof | NIPPON ZOKI PHARMACEUTICAL CO. (JP) | 1985-11-26 | — | — | US | claimed |
| EP-0083222-A1 | New quinolylacetic acid compounds and pharmaceutical compositions containing them | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1983-07-06 | — | — | EP | claimed |
| EP-0083222-B1 | NEW QUINOLYLACETIC ACID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1986-02-26 | — | — | EP | disclosed |
| US-4555513-A | 1,2 Dihydro- and 1,2,3,4-tetrahydro quinolylacetic acids and analgesic use thereof | NIPPON ZOKI PHARMACEUTICAL CO. (JP) | 1985-11-26 | — | — | US | disclosed |
| EP-0083222-A1 | New quinolylacetic acid compounds and pharmaceutical compositions containing them | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1983-07-06 | — | — | EP | disclosed |