Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | C5 | P01031 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877085 | 0.85 | AKR1C3 (0.38) | PTGS1AKR1B1AKR1C3AKR1C2APP | |
| SCHEMBL11015357 | 0.81 | AKR1B1 (0.33) | AKR1B1AKR1C3AKR1C2AKT1PPARG | |
| SCHEMBL11012237 | 0.77 | PTGS2 (0.41) | PTGS1CHRM1AKR1B1AKR1C3AKR1C2 | |
| SCHEMBL11013390 | 0.77 | HDAC4 (0.45) | PTGS1CHRM1AKR1B1AKR1C3AKR1C2 | |
| SCHEMBL11200807 | 0.75 | PTGS1 (0.39) | PTGS1CHRM1AKR1B1AKR1C3AKR1C2 | |
| SCHEMBL10840092 | 0.73 | PDE7A (0.40) | AKT1 | |
| SCHEMBL11011233 | 0.68 | MEN1 (0.56) | PTGS1CHRM1AKR1B1AKR1C3AKR1C2 | |
| SCHEMBL10963510 | 0.66 | NOTUM (0.41) | PTGS1CHRM1AKR1B1AKR1C3AKR1C2 | |
| SCHEMBL10841141 | 0.65 | AHR (0.43) | MAPTHTR2A | |
| SCHEMBL9405212 | 0.64 | AKT1 (0.41) | PTGS1AKR1B1AKR1C3AKR1C2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0083222-B1 | NEW QUINOLYLACETIC ACID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1986-02-26 | — | — | EP | claimed |
| US-4555513-A | 1,2 Dihydro- and 1,2,3,4-tetrahydro quinolylacetic acids and analgesic use thereof | NIPPON ZOKI PHARMACEUTICAL CO. (JP) | 1985-11-26 | — | — | US | claimed |
| EP-0083222-A1 | New quinolylacetic acid compounds and pharmaceutical compositions containing them | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1983-07-06 | — | — | EP | claimed |
| EP-0083222-B1 | NEW QUINOLYLACETIC ACID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1986-02-26 | — | — | EP | disclosed |
| US-4555513-A | 1,2 Dihydro- and 1,2,3,4-tetrahydro quinolylacetic acids and analgesic use thereof | NIPPON ZOKI PHARMACEUTICAL CO. (JP) | 1985-11-26 | — | — | US | disclosed |
| EP-0083222-A1 | New quinolylacetic acid compounds and pharmaceutical compositions containing them | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1983-07-06 | — | — | EP | disclosed |