Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11559423 | 0.85 | GRM5 (0.51) | NPC1MAPTHTTGRM5F2 | |
| SCHEMBL10885312 | 0.84 | GCK (0.54) | NPC1GCKFADS1 | |
| SCHEMBL11564423 | 0.82 | KDR (0.49) | NPC1MAPTHTTGRM5F2 | |
| SCHEMBL10880124 | 0.82 | ALDH1A1 (0.48) | NPC1MAPT | |
| SCHEMBL1250218 | 0.80 | ALDH1A1 (0.50) | NPC1MAPTMAPK1FADS1BTK | |
| SCHEMBL11185827 | 0.78 | CRBN (0.42) | MAPTMAPK1PIK3CAMTORBTK | |
| SCHEMBL11555940 | 0.76 | PLAU (0.36) | MAPTMAPK1PIK3CAMTORF2 | |
| SCHEMBL10880639 | 0.76 | ALPL (0.46) | NPC1MAPTMAPK1HTT | |
| SCHEMBL12892190 | 0.75 | NT5E (0.57) | NPC1MAPTGRM5F2 | |
| SCHEMBL10937080 | 0.75 | CSF1R (0.43) | NPC1MAPTGRM5SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0086340-B1 | 3-(1H-TETRAZOL-5-YL)-4(3H)-QUINAZOLINONES | THE DOW CHEMICAL COMPANY (US) | 1986-04-02 | — | — | EP | claimed |
| EP-0086340-A1 | 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinones | THE DOW CHEMICAL COMPANY (US) | 1983-08-24 | — | — | EP | claimed |
| EP-0086340-B1 | 3-(1H-TETRAZOL-5-YL)-4(3H)-QUINAZOLINONES | THE DOW CHEMICAL COMPANY (US) | 1986-04-02 | — | — | EP | disclosed |
| US-4419357-A | 3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinones | THE DOW CHEMICAL COMPANY (US) | 1983-12-06 | — | — | US | disclosed |
| EP-0086340-A1 | 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinones | THE DOW CHEMICAL COMPANY (US) | 1983-08-24 | — | — | EP | disclosed |